Peyton Manning threw for 312 yards and a touchdown as the Colts held on for a 22-20 victory over the Tennessee Titans at LP Field. Joseph Addai rushed 20 times for 81 yards and a touchdown, while Dallas Clark grabbed a 22-yard touchdown pass from Manning. Adam Vinatieri kicked three fields goals as the defending Super Bowl champions improved to 2-and-0. LenDale White ran for 64 yards and a touchdown, while Roydell Williams caught a one-yard touchdown pass as the Titans fell to 1-and-1. Vince Young finished 17-for-27 for 184 yards and a touchdown. The Colts take on Houston next on September 23rd.